2019;42:361365. If we consider elderberry and autoimmune diseases outside the thyroid, elderberry has shown itself to be great for inflammation and immune support. Active ingredient(s): Multiple anthocyanins and polyphenols, Alternate name(s): Black elder, European elder, elder flower, sambucus, Suggested dose: No standard dose, however, 2 to 4 tablespoons daily given once or in 4 divided doses daily, depending on age, is the most common dosage used in research, Safety considerations: Avoid if you are pregnant, breastfeeding, have an autoimmune disease, are taking immunosuppressants, and in children under 5 years of age. There may be a risk of hypoglycemia, and raw and . Another study published in the Journal of International Medical Research referenced above suggests that when elderberry is used within the first 48 hours of the onset of signs of flu, it can shorten the duration of flu symptoms by anaverage of four days. 2015;20;77:66-72. doi: 10.1016/j.curtheres.2015.04.001. By Jennifer Lefton, MS, RD/N, CNSC, FAND View abstract. are clickable links to these studies. There are high-quality brands readily available for purchase, or you can find many online resources for how to make elderberry syrup to try making it at home. Read our, Natural and Herbal Cold and Flu Treatments. What are the side effects of elderberry? If your diet has shifted to allow more heavy, fatty foods and you've gained weight as a result, you may notice heavier or more frequent periods, as Dr. Scott Sullivan, an associate professor of . Divinity Nutra does not provide medical advice, diagnosis, or treatment recommendations. Sambucusis a genus of flowering plants in the familyAdoxaceae. Although commercial preparations are generally safe for consumption, eating raw elderberry may cause symptoms like nausea, diarrhea and vomiting. Several studies have found benefits to support the use of elderberry for flu symptoms as well. Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks. severe weakness, dizziness, or confusion. Sambucol may cause serious side effects. Cathy Wong is a nutritionist and wellness expert. Poisoning from elderberry juice. Not all possible drug interactions are listed here. High in antioxidants, elderberries are a healthy addition to any diet and for anyone looking for delicious immune system support. Samuels N, Grbic JT, Saffer AJ, et al. This heterogeneous composition allows the berries to harness a range of health benefits. Jennifer Lefton, MS, RD/N-AP, CNSC, FAND is a Registered Dietitian/Nutritionist and writer with over 20 year of experience in clinical nutrition. These contradictions indicate it would be unjustified to generalize elderberry as a pro-inflammatory agent when many studies report its anti-inflammatory and immune support characteristics. View abstract. Also called black elder or American elder, this prolific shrub is known for its small deep purple berries that typically ripen in late summer, notes Cornell Cooperative Extension. Bioactive properties ofSambucus nigraL. as a functional ingredient for food and pharmaceutical industry. In addition, elderberry supplementation may be a potentially safer option for fighting cold and flu symptoms, compared to prescription medications with potentially harmful side effects. View abstract. In some instances, such as cold weather or pregnancy, it may temporarily increase the supply. It has deciduous leaves, white flowers (elderflowers) and berries that turn from green to red to black when ripe. In traditional or folk medicine, the elder plant was used as a laxative to relieve constipation. How much elderberry should I take for thyroid? Some researchers have suggested that the syrup shortens the duration of some illnesses and makes them less severe; however, the study findings have varied. Available at: https://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009). There is no safety data on the use of elderberry in children under 5 years of age. View abstract. Elderberry may reduce the effectiveness of immune suppressants, which are common medications for people who have undergone organ transplant procedures. With elderberrys anti-inflammatory and antioxidant properties, it makes sense that it can help treat sinus issues and diseases related to respiratory health. Inflammatory cytokines, An evidence-based systematic review of elderberry and elderflower (, Chemical profiling and UHPLC-QToF analysis for the simultaneous determination of anthocyanins and flavonoids in Sambucus berries and authentication and detection of adulteration in elderberry dietary supplements using UHPLC-PDA-MS, 2021 US open forum: elderberry standards development, A 2020 study did not find black elderberry to improve symptoms or reduce the amount of time of illness. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Elderberry is a berry from a European or Black elder tree. Do not give any herbal/health supplement to a child without medical advice. One group was given four doses of 175-milligram proprietary elderberryextract daily, and the other group received a placebo for two days. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. In addition to black elderberry, there are several other varieties available as well. First, check the package for the daily recommended dosage, and don't exceed that amount, states the University of Rochester Medical Center. The berries are credited for many feats including, but not limited to: Now, lets see what the research says about using elderberry for thyroid support. View abstract. This information may not fit your specific health circumstances. Because taking this nutritional supplement could potentially result in elderberry side effects, err on the side of caution. The berries and flowers of the elder plant are used as medicine. Taking a specific elderberry extract syrup (Sambucol, Nature's Way) seems to reduce. 2021;21(1):112. doi:10.1186/s12906-021-03283-5, Macknin M, Wolski K, Negrey J, Mace S. Elderberry extract outpatient influenza treatment for emergency room patients ages 5 and above: a randomized, double-blind, placebo-controlled trial. Roschek B, Fink RC, McMichael MD, et al. Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food a review. Not a fan of hot teas or black elderberry syrup? One study evaluating elderberry products on the market found that many did not contain elderberry. Leads from the MMWR. Picon PD, Picon RV, Costa AF, et al. Elderberry appears to have few side effects when used properly for short periods of time of up to five days. Schroder-Aasen T, Molden G, Nilsen OG. Sometimes, good things do come in small packages. Elderberry has not been proven to prevent COVID-19 Some have even relied on elderberry products to help ease the effects of cancer, depression and HIV/AIDS. Because of its powerful effects on health, elderberry supplements could potentially interact with several medications. Occasionally, however, elderflowers and elderberries can cause allergic reactions. Hashimotos thyroiditis and other autoimmune diseases are serious conditions and must be handled with care. Products are available in many forms, including: In addition to the various forms, elderberry is available as a single supplement or in combination with other nutrients. While these results are promising, further large-scale human studies are. If you're using your own preparation, cooking it neutralizes poisonous substances. View abstract. Its a deciduoustree growing up to 32 feet tall with cream-white flowers and blue-blackberries. Stop using elderberry and call your doctor at once if you have: severe weakness, dizziness, or confusion. Be aware that elderberry has not been connected to any negative interactions with specific foods or medicines, stresses the Mayo Clinic. Since homemade/artisan syrups might contain small amounts of cyanide, usethem cautiously. Elderberry has antioxidant properties that may be beneficial for balancing blood sugar in diabetes, but current evidence is limited. The benefits seem to be greatest when started within 24 to 48. Clinical effectiveness of a combination of black elder berries, violet herb, and calendula flowers in chronic obstructive pulmonary disease: the results of a double-blinded placebo-controlled study. Elderberry is marketed mostly for immune support. There is limited data on the uses of elderberry other than viral infection symptom management. Is elderberry recommended to prevent COVID-19? 2016 Mar 24;8(4). Here are the areas in which experts think elderberry shows major promise. Elderberries should always be cooked and processed before theyre consumed. Supplementation can assist your healing process, but severe cases of thyroid dysfunction may require extensive medication or surgery. Collectively, this analysis included 180 participants with upper respiratory symptoms. Use exactly as directed on the label, or as prescribed by your healthcare provider. Tea enthusiasts often brew the dried flowers into a sweet-tasting hot elderberry tea with benefits similar to the syrups or other preparations. Using elderberry supplements for kids is not recommended unless youve consulted with your pediatrician. In addition, the boiling process removes additional nutrients. The optimum dosage is 150-300 mg of elderberry extract per day. Barak V, Halperin T, Kalickman I. Antibiotics, however, do not directly affect your menstrual cycle. The group treated showedsignificant improvement in most signs of flu, whilethe placebo group showed no improvement in symptom severity. The elderberry side effects are limited, rare, and often mild. Increased fiber consumption has been shown to improve your gastrointestinal system function. However, even if supplements are third-party tested, that doesn't mean they are necessarily safe for all or effective in general. Cao G, Prior RL. Even the bark of the plant was used for its diuretic and slimming effects. For example, several forms are marketed for immune support, and they also contain vitamin C, zinc, vitamin A, or vitamin E. This is especially important with elderberry products. Nutrients. A 2016 study published inNutrientsshowed that elderberry supplementation was able to reduce cold duration and symptoms in people using air travel. These can include a change in your blood pressure or an unusually rapid heartbeat. Complement Ther Med. Although studies have found mixed results, some research suggests that elderberry extract may improve heart health. Elderberry is available in many different types of products, including syrups and mouth rinses. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years experience in consumer-oriented health and wellness content. Specifically, elderberry is not on the list of herbal supplements known to interact negatively with widely used heart medications. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. Research has confirmed thatextracts of elderflower stimulate glucose metabolism and the secretion of insulin, which could potentially help lower blood sugar levels. Elderberry extract has been found to help reduce the length and severity of symptoms caused by the influenza virus. Jennifer Lefton, MS, RD/N-AP, CNSC, FAND is a Registered Dietitian/Nutritionist and writer with over 20 years of experience in clinical nutrition. If you want fresh berries, be sure you buy them from a reputable source. Some information suggests that elderberry can increase inflammatory cytokine production, which is a part of a healthy immune system response. It was added to herbal mixtures to improve regularity. There are also recipes for elderberry-based medications dating back toAncient Egypt. Grbic J, Wexler I, Celenti R, et al. The major elderberry (Sambucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome-inactivating protein. These powerful little berries have a higher flavonol content than blueberries, blackberries, cranberries and goji berries. Part 182 -- Substances Generally Recognized As Safe. Although not all side effects are known, elderberry is thought to be possibly safe when taken as directed for a short period of time. This may lead to an underactive thyroid or hypothyroidism, meaning insufficient thyroid production. J Funct Foods. 2020;9(4):83. doi: 10.3390/biology9040083. Clin Chem 1999;45:574-6. During the fifth century B.C., Greek physicians and philosophers wrote of the elder tree's healing abilities. Compared to other types of berries, elderberry is the clear winner. 2017;31(4):533-554. doi:10.1002/ptr.5782, Wieland LS, Piechotta V, Feinberg T, et al. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Forster-Waldl E, Marchetti M, Scholl I, Focke M, et al. If you make your own syrup, rather than buying it in a health food or grocery store, you can safely store it in the refrigerator for three months. Mol Nutr Food Res. Another study found that elderberry extract may have beneficial effects on high blood pressure. In rare cases, they can completely block your periods. Just be sure not to purchase one that has too much added sugar. Does elderberry interact with medications? One cup of elderberries provides 106 calories, 27 grams (g) of carbohydrates, 10 g of fiber, 52 milligrams (mg) of vitamin C, 2.3 mg of iron, and 406 mg of potassium. These include the: Unripened, raw elderberries can release cyanide into your body and make you sick. Thank you, {{form.email}}, for signing up. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Elderberry should not be confused with American Elder, Elderflower, or Dwarf Elder. If you have diabetes or experience lipid disorder, be cautious of the quantity you consume. J.Clin.Dent. Elderberry extract is possibly safe when taken for up to 12 weeks. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. The dark, purplish berries are frequent supporters of bodily healing in Ayurveda, the worlds oldest branch of natural medicine. Elderberry supplementation reduces cold duration and symptoms in air-travellers: a randomized, double-blind placebo-controlled clinical trial. Although some studies suggest that elderberry can provide some symptom relief, larger-scale research is needed in order to prove the efficacy of using elderberry syrup for colds. Given the need for a nutrient-rich diet for the thyroid, this is a minor disadvantage of using syrups. Using this antiviral herb is not recommended for women who are pregnant or breastfeeding, children, or those with autoimmune disorders. Keep your supplements stored according to the instructions on the product label. Call your doctor for medical advice about side effects. Macknin M, Wolski K, Negrey J, Mace S. Elderberry extract outpatient influenza treatment for emergency room patients ages 5 and above: a randomized, double-blind, placebo-controlled trial. Europeanelderberry(Sambucusnigra) is known for its medicinal use and contains anthocyanins, flavonoids and other polyphenolics, which all contribute to the high-antioxidant capacity of its berries. It is marketed for several other conditions as well, but research is lacking. But, is elderberry good for thyroid disorders and autoimmune diseases? Van Damme EJ, Roy S, Barre A, et al. If you have any other ongoing health concerns, talk with your health care provider before taking it as well. If you appreciate foods that are pleasing to your taste buds and that also seem to offer health benefits and practical uses, you're likely acquainted with black elderberry. Doctors prescribe diuretics when the body retains too much fluid, which is a common problem in older adults. Elderberry may cause serious side effects. However, the U.S. National Library of Medicine highlights a February 2019 meta-analysis of controlled, randomized clinical trials on elderberry use for cold and flu symptoms. Since there is no standard dosage, however, consult your healthcare provider or pharmacist and read the dosage directions on the product label before taking it. Methods Find Exp Clin Pharmacol. Chemical profiling and UHPLC-QToF analysis for the simultaneous determination of anthocyanins and flavonoids in Sambucus berries and authentication and detection of adulteration in elderberry dietary supplements using UHPLC-PDA-MS. Journal of Food Composition and Analysis. An evidence-based systematic review of elderberry and elderflower (Sambucus nigra) by the Natural Standard Research Collaboration. The study found thatan aqueous extract of elder significantly increased glucose transport, glucose oxidation and glycogenesis without any added insulin. Elderberry is also promoted for treating high cholesterol, relieving pain, having anti-inflammatory properties, and more. Not only that, but researchers also suspect thatacompound found in theberry could give a natural boost to skin. U.S. Department of Agriculture: FoodData Central. That said, there is no benefit to taking elderberry every day, as it does not prevent illness. The raw berries are made up of 80 percent water, 18 percent carbohydrates, and less than 1 percent each of protein and fat. View abstract. You may report side effects to FDA at 1-800-FDA-1088. Stop using elderberry and call your doctor at once if you have: severe or ongoing vomiting or diarrhea; numbness; or severe weakness, dizziness, or confusion. Elderberries contain many vitamins and nutrients that can benefit people's health. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have an autoimmune disease such as: Ask a doctor before using this product if you are pregnant or breastfeeding. Only take the amount recommended on the label. Elderberry is most commonly used orally as a syrup. Elderberry extract appears to be safe when taken in small doses. If you've thought about taking an elderberry supplement, know that the deep purple berries are packed with desirable nutrients. pii: E182. Some of the most common include: European elder flowers contain approximately 0.3 percent of an essential oil composed of free fatty acids and alkanes. Its never safe to eat unknown berries in nature, as they may have dangerous effects. Raw unripe elderberries and other parts of the elder tree, such as the leaves and stem, contain toxic substances (e.g., sambunigrin) that can cause nausea, vomiting, and diarrhea; cooking eliminates this toxin. A diuretic is a substance that promotes the production of urine. If you have an autoimmune disease, such as rheumatoid arthritis, ask your doctor before taking elderberry supplements because it may stimulate the immune system. Reportedly, the possibility of a cytokine storm due to COVID can worsen the inflammation and dysfunction of the thyroid. This can cause nausea, vomiting, and diarrhea, or more serious side effects if consumed in large quantities. Title 21. It is available at many local health stores and online retailers and can be purchased in a variety of different forms. 2020;35(11):3271-3277. doi:10.1007/s11606-020-06170-w, Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. View abstract. Samuels N, Saffer A, Wexler ID, et al. In addition, stay alert for potential elderberry side effects. It is not outwardly visible but consists of two lobes found on either side of your windpipe. When it comes to colds, flu and upper respiratory issues, elderberry syrup is very popular. Unripened, raw elderberries can release toxins into your body. Another popular way to consume elderberries is to purchase an elderberry syrup. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Even ripe berries can contain trace amounts, so elderberries must be cooked before you eat them. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Dosage: How Much Elderberry Should I Take? Unfortunately, direct research examining Hashimoto's disease is limited. Lets take a look at the research to find an answer. This herb is available in syrup, juice and tea form. Other drugs may affect elderberry, including prescription and over-the-counter medicines, vitamins, and herbal products. The history starts from the Hippocrates era in 400 BC to early Europe and America. View abstract. Elderberry gummies are your best bet if they come with both zinc and vitamin C. If purchased from a trusted brand, gummies provide a tasty and easy way to make elderberry a part of your diet without swallowing capsules. When considering the use of herbal supplements, seek the advice of your doctor. In vitro inhibition of CYP3A4 by the multiherbal commercial product Sambucus Force and its main constituents Echinacea purpurea and Sambucus nigra. It can be used for allergies on its own or in combination with other herbs and natural remedies. Today, black elderberry (Sambucus nigra) is one of natures most effective solutions for ailments. If you decide to make your own elderberry syrup or similar product, obtain instructions from a reputable source and follow the directions exactly. Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. 2018;40:377-390. doi:10.1016/j.jff.2017.11.025, Porter RS, Bode RF. It also contains flavonoids, which have antioxidant propertiesthat canhelp prevent cell damage, andanthocyanidins, which are chemical compounds that are known to have immune-boosting properties. Since allergies involve an overreaction of the immune system as well as inflammation, research suggests that the herbs ability to improve immune function and calm inflammation can help provideallergy relief. 2021 US open forum: elderberry standards development. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Elderberry use is considered safe for up to 12 weeks. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Black Elderberry 101 Everything You Need to Know, 10 Best Sambucus Elderberry Gummies for 2023, Elderberry Gummies: Benefits and Nutrition Facts. It contains very high amounts of anthocyanins, flavonoids, dietary fiber, and vitamins. This includes: There is no standard recommendation for dosing elderberry. Drug class: Herbal products. Answer (1 of 4): Long-Term Supplementation of Black Elderberries Promotes Hyperlipidemia, but Reduces Liver Inflammation and Improves HDL Function and Atherosclerotic Plaque Stability in Apolipoprotein E-Knockout Mice. Specifically, the flavonoids in the berries bind tothe H1N1 human influenza virus as well asthe H5N1 avian influenzavirus. View abstract. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If youre on chemotherapy or take diabetes medications, diuretics, immunosuppressants, laxatives or other medications, talk to your doctor before starting supplementation. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. One such supplement is elderberry, which has a long history of efficacy for inflammation and immune support. If you have a preexisting thyroid condition, its best to speak with a doctor before adding elderberry into your treatment regimen. Heres what you need to know, including its many benefits. The symptoms are similar to the more frequently occurring diseases, so diagnosing and treating the problem isnt always straightforward. A 2009 study randomized patients intotwo groups. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. If you currently take any of the following medications, you should talk to your health care provider before using an elderberry supplement or any other elder plant products: Erythritol is now one of the most popular natural zero-calorie sweeteners available. Clin Exp Allergy 2003;33:1703-10. 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Studies report its anti-inflammatory and immune support characteristics local health stores and online retailers and can be purchased in variety! Want fresh berries, be cautious of the quantity you consume common in. Be unjustified to generalize elderberry as a laxative to relieve constipation Hippocrates in! Drug approvals, alerts and updates result in elderberry side effects when used properly for short periods time... Deciduoustree growing up to 12 weeks unless youve consulted with your health care provider before it! To skin make you sick much added sugar of elderflower stimulate glucose metabolism and the other group received placebo! Are a healthy addition to any negative interactions with specific foods or medicines vitamins... That elderberry supplementation was able to reduce cold duration and symptoms in people using air travel commercial are...