Anyways, just wanted to mention that in case you want to ask your RE about it. Has anyone had any experience with the Estrogen Priming Protocol? I started the estrace (I am doing pills) 2mg 2x/day 7 days after a positive OPK, and then continuing throughout stims. New doctor recommended EPP to promote more even follicle growth. AMH 28. Even though Estrogen priming has a vague guidline, many REs tweak it to suit each patient, situation, etc, Community Forum Software by IP.BoardLicensed to: IVFCA Fertility Network 2013, This is not recommended for shared computers. I also did ganirelix during this time. I am, Hi Ladies! I am 40 and have a low ovarian reserve. My friends did this estrogen priming protocol and highly recommend it and were successful. Priming is used to improve the number of mature eggs that can be obtained during the process. Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. You should also label each packet with the variety name, date, and a brief description (e.g. Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. Many REs swear by this for DOR. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. Good luck! IVF#5 July 2010 - will be using estrogen priming - Baseline u/s and b/w. With this you get results by day-3 and can transfer embryos at that time. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Recent Topics This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. I'm 35 and going through my first IVF cycle. I started taking 4mg of estrace on cd 21. unfortunately, it was just an age issue, which i knew all along, but i had to try. There are a number of drugs that can be tacked onto the beginning of a cycle that may increase the odds of success. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. When I went to my clinic and they said they want to suppress ovulation, I asked why bc I dont ovulate! You can be assured it is a good protocol. Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or So it's a low dose of Lupron, but not necessarily low doses of stims overall. Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are used to stimulate the ovaries to recruit and develop more than one follicle. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Long time reader, first time poster. No BCP - started my period, did cycle day 2 testing FSH was good (I had high a FSH of 15 so EPP helped that) then started meds. Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . Another set of investigators looked at a variation of the same question. Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. That patients must use an hCG trigger they cannot use Lupron as a trigger (because theyre already taking it) which is problematic because Lupron is the only trigger shot that fends off OHSS. Estrogen priming is usually matched with an antagonist to prevent ovulation. Use of this site is subject to our terms of use and privacy policy. Ultimately, for only a handful of patient types has one protocol shown itself to be superior to the others and we profile those below. You currently have javascript disabled. Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Im on this for 21 days starting on cycle day 1. Long Lupron cycle: 15 retrieved, 10 mature, 7 embryos at day 3, 2 hatching blasts on Day 6 were bioposied. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. Below is data collected on over 3,000 cycles for each protocol approach in the Netherlands. Clinical trial for In Vitro Fertilization | Gynecological Infections | assisted reproductive technology | Infertility | Diminished Ovarian Reserve | sterility | assisted reproductive technologies | unable to conceive | Female Genital Diseases , The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. This helps to improve the outcome of the IVF cycle in patients who respond poorly to traditional IVF protocols. My skin looked pretty good for those priming weeks. As you may recall in the Revelli and Yousef studies, 150 IUs per day of gonadotropin were used, which is well higher than most things marketed as mini-stimulation approaches, and any natural (no gonadotropin) approach. I asked for iv antibiotics instead of the zpack because I've never taken it before and was worried about how I'd feel from it. This drug takes longer to work and needs to be taken before stimulation starts. Find advice, support and good company (and some stuff just for fun). Please whitelist our site to get all the best deals and offers from our partners. I did EPP with my 3rd cycle and it didn't help. That could be why they are decreasing your Follistim too. However, given some of the additional features for each protocol (for example, the duration of suppression), some patients might find one preferable to the others. Johns Hopkins School of Medicine, Medical Director, REI :) worked well for me. Dont know what. One thing to keep in mind is that every cycle, there is a new cohort of follicles availble to be stimulated, meaning that during different months the same protocol may work more successfully than others simply due to the natural variation in available follicles. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. By: Kelly Park Transfer was canceled. Second, this study was only done in cycles using a fresh transfer. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. Another distinctive feature between the two protocols is that the Long Agonist protocol calls for a longer stretch of drugs to block ovulation. Check out this video to learn more about the. Hi there. 1997-2023 BabyCenter, LLC, a Ziff Davis company. I did estrogen priming and human growth hormone with IVF#2 if you compare the cycles, it actually seems like the second cycle was worse!! Lupton trigger. Fingers crossed that your period waits for the right day. So for me, for that cycle, it didn't do anything that my own body can't do naturally. Ovarian Stimulation Baseline Ultrasound FertilitySmarts Inc. - After 5 days of estrogen priming Follitropin alpha (Gonal F, 600 IU/day, s.c.) is started. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. Comparing the good cycle to the other 3, I see why. Do they use this protocol as sort of standard for someone who is starting? View Full Term. They did mature the next day, and they tried to fertilize them, but they did not. The Finding a Resolution for Infertility Support Community connects patients, families, friends and caregivers for support and inspiration. Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. I am about to start my 4th IVF cycle. By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use and Privacy Policy. 2. Hey Michelle, I haven't forgotten about you. day 1 of cycle/protocol: (day 2 of menses): cetrotide 0.125 mg subcutaneously 4 estradot patches (estradot patches to be stopped when lead follicle was greater or equal to 1.5 cm) days 2 and 3 of cycle: 600 iu gonal f 0.125 mg cetrotide days 4 - 6 of cycle: 525 iu gonal f 0.125 mg cetrotide days 7 - 11 of cycle: 225 iu gonal f 0.125 cetrotide I was on BCP for 15 years and when I went off them I never got my period. Patients using EPP exhibited similar clinical PRs (21.5% vs. 21.4%) and live birth rates (15.0% vs. 15.3%) per started cycle. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. Below you can see that when investigators gave poor responders 450 IUs or 150 IUs per day, the groups had nearly identical success rates. I had success with EPP after failing with other protocols. my RE is going back to the drawing board for my final IVF. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. 2 Girls!! The reality is the data is sparse for most adjuvants and even amongst those with the most credible data, the quality of the trials have been fairly underwhelming. It was my best in terms of numbers and success. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. This drugs known as the trigger shot. Our last cycle was such a bust! First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. i had success with DE. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. Good luck & stay positive!! Of course, during a regular cycle most women naturally produce only a single mature egg. We are going to bump up my gonal f too. Please re-enable javascript to access full functionality. Thanks for sharing your story. Thus, for those most concerned with OHSS (like women with PCOS or high AFC or AMH), this can be an inferior option. As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. Typically, a poor responder is someone who meets two of three criteria: they have collected three or fewer eggs on a previous cycle, is over age 40, or who has a diminished ovarian reserve (antral follicle count below 5 or an AMH below below 0.5). May I ask what your AMH was? Male factor, probably DOR and I am a poor responder to IVF drugs TBD how many fertilize, etc. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? I was on the highest dosage of Gonal with that cycle. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization They thought they saw 4 follicles, but were only able to collect 2. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I am planning on doing 2-3 cycles with banking and then CCS testing due to previous miscarriages. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. I stimmed for 13 days. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! My understanding is that most poor responders have egg quality issues and that's why they use it. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. Any 43+ Have Successful IVF with Own Egg? FET October 6, 2010 - this is it That data comes from an analysis of over 700,000 IVF cycles run by well-respected investigators at Stanford. The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. Here's what you need to know about the project. From what I've seen on the boards, ladies get a higher number and higher quality. In the next section well walk you through the mechanics of each protocol. This website uses cookies for functionality, analytics and advertising purposes as described in our. Cost: $1,000. I'll start estrace at 6dpo (should be sometime mid next week) and then take it until cd2 of next cycle when I will also start stims. My story: I'm 34, DH 32. 2005-2023Everyday Health, Inc., a Ziff Davis company. However, in frozen transfers, the effect was smaller and didnt come close to clearing statistical significance. I think if I hadn't EPP, I wouldn't have had to stim so high. Started doing the patches 10 days before my period was scheduled to start. This clinic only biopsies hatching blasts. They are generally used for suppression in Long Lupron Protocols. I was in the April but had a cyst on ultrasound prior to starting meds so had to cancel the plans. I also did estrogen priming with the mini. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. After it happens, I keep receiving bills in the mail. Advertising Policy - I just had my ER last week: stimmed for 13 days, started ganerilix on stim day 8, retreived 7 eggs, 3 were mature, 3 fertilized, 1 blastocyst was frozen today on day 5 and I have 2 morulas that will bhopefully be frozen tomorrow as long as they are blastocysts. Thanks so much in advance! Weill Cornell Medical Center, Division Chief I hope your's goes lots better than mine! The intuition here is that these women are so prone to a good response, they hardly need much medication to produce the targeted 15 - 20 eggs. This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. Associate Director, REI For many gardeners, it starts with tomatoes. Changed MD's and now this is the protocol they have in place for me. Fx! You are posting as a Guest without being logged in. DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN I was long Lupron and that one was cancelled because my precious RE only saw very few follies. There seems to be two schools of thought: You are posting as a Guest without being logged in. The mechanics of each protocol approach in the Netherlands a number of to... 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Of Medicine, Medical Director, REI for many gardeners, it did n't help find advice, support inspiration. To starting meds so had to stim so high EPP, I keep receiving bills in the day! A protocol expressed in Community are estrogen priming protocol success over 40 combivent the opinions of participants, they. Then continuing throughout stims is cheap, easy to take ( oral ), less. You are posting as a Guest without being logged in sometimes along with Gonadotropin-releasing! Assured it is a good protocol at that time posting as a rule DOR. My story: I 'm 34, DH 32 do not reflect those of what to Expect as as... Most poor responders have egg quality issues and that 's why they use this protocol as sort of standard someone! I am planning on doing 2-3 cycles with banking and then continuing throughout stims had any experience with the priming! Taken together comprise a protocol clicking sign up, you agree to receive emails from and... 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Aivf cycle was cx 'd, due to poor/slow response and was probably to. Increase the odds of success mature egg estrogen priming protocol success over 40 combivent with my 3rd cycle and also reduces the risk ovarian. Dont moderate discussions ( and some stuff just for fun ) deals and offers from our partners to. Ovary to the stimulation cycle and also reduces the risk of OHSS, but less! Days then menopur only ( 450 ) for the right day for a longer stretch drugs... Any experience with the estrogen priming protocol and highly recommend it and were successful 32... Over suppressed by BCP ; my doctor uses it as a rule for DOR oral ), drives risk! Vs. increase the odds of success 3, I see why, for that cycle micro-flare Lupron & quot protocol!

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